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Chasing the Curve/Chapter 3
03

Building a Case Definition

The Person / Place / Time triad

Step 4 of the checklist (the working case definition) is the foundation everything else is built on. A good case definition always answers three questions, known as the person, place, and time triad:

CDC lists it as clinical criteria (symptoms, lab results) plus limits on person, place and time. On a test, name the clinical criteria as well as person, place and time.

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Person

Who counts as a case? Set clinical criteria (symptoms, lab results) and sometimes limits like age group or occupation.

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Place

Where does a case have to be located? A school, a restaurant's customers, a specific ZIP code or region.

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Time

When did illness onset have to occur? A specific date range tied to the suspected exposure window.

๐Ÿ” Try It: Writing a Case Definition

Twenty students at Cedarwood Middle School's spring banquet report stomach illness the same evening. A working case definition might read:

Case: Any student or staff member who attended the Cedarwood Middle School spring banquet on May 3 (place) and developed vomiting or diarrhea (person: clinical criteria) within 12 hours after the event (time).

Notice the definition doesn't try to name the cause yet: it just draws a clear, repeatable line around who counts.

Leave the suspected exposure out. Don't write "and ate the potato salad" into a case definition. The whole point of the study that follows is to compare the ill and the well on what they ate; if eating the salad were part of being a case, every case would have eaten it by definition, and the salad would look guilty no matter what.

Case definitions often tighten over time. Investigators frequently start broad (to catch every possible case) and then split results into confirmed, probable, and suspect categories as lab results come back, narrowing the definition as evidence accumulates. A broad definition is more sensitive (it misses fewer real cases) but less specific (it lets in more people who aren't really cases); adding lab confirmation or stricter symptoms does the reverse. Lab criteria are included when a test is available, but they aren't required: many working definitions are clinical only.

Sorting people into case tiers

Confirmed

Usually a positive lab test for the agent. Each disease's case definition sets the exact rules.

Probable

The typical signs and symptoms (often plus a link to the outbreak), but no lab confirmation yet: the test is pending or wasn't done.

Possible (suspect)

Only some of the symptoms, not the full clinical picture, and no lab confirmation.

Not a case

Doesn't meet the case definition, or a lab test found a different agent or ruled the disease out.

Edge Cases Tests Love

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No symptoms, positive lab

Confirmed for some diseases (like Salmonella) but not others (measles needs a fever and rash too). Check that disease's case definition.

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Every symptom, wrong germ

A lab result for a different pathogen means not a case, even though the person looks sick.

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Caught somewhere else

An imported case got the disease elsewhere, like a traveler who got measles abroad in the 21 days before their rash. It can start a local outbreak, but it isn't counted as locally acquired.

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Linked to a confirmed case

For some diseases a link to a confirmed case is enough. Under the measles definition, someone with the typical illness who had contact with a lab-confirmed case is confirmed, even with no test of their own.

The tiers above are the general pattern. When a question gives a disease's own case definition, follow that.
TryClassify: (a) vomiting and diarrhea, lab pending; (b) only nausea, no test; (c) no symptoms, stool test positive for the outbreak germ; (d) vomiting and diarrhea, stool test found a different germ. (Assume this food poisoning outbreak's definition counts a positive stool test as confirmed.)
(a) Probable. (b) Possible. (c) Confirmed. (d) Not a case.
Some diseases, like measles, count a case as confirmed only if the person is also sick.

โœ“ Check Yourself

Q1A case definition says: "Anyone who attended Lincoln Elementary's book fair between March 4 and 6 and developed a rash within 48 hours." Which part is the "place"?

Q2Person, place or time? Sort each part of these case definitions.

Q3A guest at the reunion has all the typical symptoms, but no lab test was done. Using the confirmed / probable / possible tiers, how is this guest classified?